Cargando…

Safety of anti-VEGF treatments in a diabetic rat model and retinal cell culture

PURPOSE: To analyze the safety of different concentrations of anti-VEGF on retinal cells. METHODS: Non-diabetic and streptozotocin (STZ)-induced diabetic rats received intravitreal rat anti-VEGF injections that had final vitreous concentrations of 0, 0.0625, 0.125 (clinical dose), and 0.25 mg/mL. Ra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Filek, Richard, Hooper, Phil, Sheidow, Tom G, Liu, Hong, Chakrabarti, Subrata, Hutnik, Cindy ML
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616316/ https://www.ncbi.nlm.nih.gov/pubmed/31308619 http://dx.doi.org/10.2147/OPTH.S199771

Ejemplares similares

Two-year analysis of changes in the optic nerve and retina following anti-VEGF treatments in diabetic macular edema patients
por: Filek, Richard, et al.
Publicado: (2019)

Impression cytology implicates cell autophagy in aqueous deficiency dry eye
por: Lin, Tony, et al.
Publicado: (2017)

Efficacy of various antioxidants in the protection of the retinal pigment epithelium from oxidative stress
por: Kagan, Dov B, et al.
Publicado: (2012)

ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy
por: Wu, Yuexiu, et al.
Publicado: (2010)

Effects of anti-VEGF agents on rat retinal Müller glial cells
por: Guo, Bin, et al.
Publicado: (2010)

Aqueous misdirection syndrome: an interesting case presentation
por: Moinul, Prima, et al.
Publicado: (2015)

Safety profiles of anti-VEGF drugs: bevacizumab, ranibizumab, aflibercept and ziv-aflibercept on human retinal pigment epithelium cells in culture
por: Malik, Deepika, et al.
Publicado: (2014)

C-peptide and Retinal Microangiopathy in Diabetes
por: Chakrabarti, Subrata, et al.
Publicado: (2004)

Outer retinal tubulation in diabetic macular edema following anti-VEGF treatment
por: Al-Halafi, Ali M
Publicado: (2015)

Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections
por: Levin, Ariana M, et al.
Publicado: (2017)

Long-term efficacy and safety of anti-VEGF therapy in retinitis pigmentosa: a case report
por: Miyata, Manabu, et al.
Publicado: (2018)

Combined Tractional and Rhegmatogenous Retinal Detachment in Proliferative Diabetic Retinopathy in the Anti-VEGF Era
por: Hsu, Ya-Jui, et al.
Publicado: (2014)

The value of corneoscleral rim cultures in keratoplasty: a systematic review and cost-effectiveness analysis
por: Kiatos, Efstathia, et al.
Publicado: (2017)

North American cost analysis of brand name versus generic drugs for the treatment of glaucoma
por: Malvankar-Mehta, Monali S, et al.
Publicado: (2019)

Trends in Glaucoma Filtration Procedures: A Retrospective Administrative Health Records Analysis Over a 13-Year Period in Canada
por: Kansal, Vinay, et al.
Publicado: (2020)

SIRT1 reduction causes renal and retinal injury in diabetes through endothelin 1 and transforming growth factor β1
por: Mortuza, Rokhsana, et al.
Publicado: (2015)

Clinical effectiveness of currently available low-vision devices in glaucoma patients with moderate-to-severe vision loss
por: Patodia, Yogesh, et al.
Publicado: (2017)

Regional Variety of Reduction in Retinal Thickness of Diabetic Macular Edema after Anti-VEGF Treatment
por: Yamada, Yutaka, et al.
Publicado: (2022)

Anti-VEGF treatment and peripheral retinal nonperfusion in patients with central retinal vein occlusion
por: Abri Aghdam, Kaveh, et al.
Publicado: (2017)

Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relevance in Diabetic Retinopathy
por: Ruiz, Michael Anthony, et al.
Publicado: (2015)

An experimental study of VEGF induced changes in vasoactivity in pig retinal arterioles and the influence of an anti-VEGF agent
por: Su, Er-Ning, et al.
Publicado: (2012)

Impact of Intravitreal Anti-VEGF Therapy on Microperimetry of the Retinal Nonperfusion Areas of Patients with Proliferative Diabetic Retinopathy
por: Parravano, Mariacristina, et al.
Publicado: (2022)

Deep Ensemble Learning for Retinal Image Classification
por: Ho, Edward, et al.
Publicado: (2022)

Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases
por: Seah, Ivan, et al.
Publicado: (2020)

VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy
por: Arrigo, Alessandro, et al.
Publicado: (2022)

Differential effects of curcumin on vasoactive factors in the diabetic rat heart
por: Farhangkhoee, Hana, et al.
Publicado: (2006)

Efficacy and safety of pan retinal photocoagulation combined with intravitreal anti-VEGF agents for high-risk proliferative diabetic retinopathy: A systematic review and meta-analysis
por: Fu, Peng, et al.
Publicado: (2023)

Diabetic Retinopathy: From Pathogenesis to Treatment
por: Chakrabarti, Subrata
Publicado: (2007)

Anti-VEGF for the Management of Diabetic Macular Edema
por: Stefanini, Francisco Rosa, et al.
Publicado: (2014)

Branch Retinal Vein Occlusion, Macular Ischemia, and Intravitreal Anti-VEGF Therapy
por: Bertelmann, Thomas, et al.
Publicado: (2017)

Correction: Use of biomaterials for sustained delivery for anti-VEGF to treat retinal diseases
por: Seah, Ivan, et al.
Publicado: (2020)

Anti-VEGF-Resistant Retinal Diseases: A Review of the Latest Treatment Options
por: Wallsh, Josh O., et al.
Publicado: (2021)

Progress and Challenges of Anti-VEGF Agents and Their Sustained-Release Strategies for Retinal Angiogenesis
por: Xu, Manhong, et al.
Publicado: (2022)

Observation, laser photocoagulation or anti-VEGF therapy in the management of retinal arterial macroaneurysms
por: Wang, Yuelin, et al.
Publicado: (2022)

Needs assessment of ophthalmology education for primary care physicians in training: comparison with the International Council of Ophthalmology recommendations
por: Chan, Toby YB, et al.
Publicado: (2011)

3-D OCT angiographic evidence of Anti-VEGF therapeutic effects on retinal capillary hemangioma
por: Otero-Marquez, Oscar, et al.
Publicado: (2022)

Preclinical Efficacy and Safety of VEGF-Grab, a Novel Anti-VEGF Drug, and Its Comparison to Aflibercept
por: Hong, Hye Kyoung, et al.
Publicado: (2020)

Gene profiling of human VEGF signaling pathways in human endothelial and retinal pigment epithelial cells after anti VEGF treatment
por: Golan, Shani, et al.
Publicado: (2014)

Mature vessel occlusion after anti-VEGF treatment in a retinal arteriovenous malformation
por: Chuang, Lan-Hsin, et al.
Publicado: (2013)

Therapeutic effect of dexamethasone implant in retinal vein occlusions resistant to anti-VEGF therapy
por: Wallsh, Josh, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_44kjmkd97gr0u2bc8gkjjavneg