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How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch

Spinal transmission of pruritoceptive (itch) signals requires transneuronal signaling by gastrin-releasing peptide (GRP) produced by a subpopulation of dorsal horn excitatory interneurons. These neurons also express the glutamatergic marker vGluT2, raising the question of why glutamate alone is insu...

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Detalles Bibliográficos
Autores principales: Pagani, Martina, Albisetti, Gioele W., Sivakumar, Nandhini, Wildner, Hendrik, Santello, Mirko, Johannssen, Helge C., Zeilhofer, Hanns Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616317/
https://www.ncbi.nlm.nih.gov/pubmed/31103358
http://dx.doi.org/10.1016/j.neuron.2019.04.022