Identification of ryuvidine as a KDM5A inhibitor

KDM5 family members (A, B, C and D) that demethylate H3K4me3 have been shown to be involved in human cancers. Here we performed screening for KDM5A inhibitors from chemical libraries using the AlphaScreen method and identified a battery of screening hits that inhibited recombinant KDM5A. These compo...

Descripción completa

Detalles Bibliográficos
Autores principales: Mitsui, Eishin, Yoshida, Shogo, Shinoda, Yui, Matsumori, Yasumasa, Tsujii, Hiroshi, Tsuchida, Mie, Wada, Shuichi, Hasegawa, Makoto, Ito, Akihiro, Mino, Koshiki, Onuki, Tetsuo, Yoshida, Minoru, Sasaki, Ryuzo, Mizukami, Tamio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616564/
https://www.ncbi.nlm.nih.gov/pubmed/31289306
http://dx.doi.org/10.1038/s41598-019-46346-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616564/
https://www.ncbi.nlm.nih.gov/pubmed/31289306
http://dx.doi.org/10.1038/s41598-019-46346-x

Ejemplares similares