Cargando…
Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors
Bisphenol A (BPA) is used as an industrial raw material for polycarbonate plastics and epoxy resins; however, various concerns have been reported regarding its status as an endocrine-disrupting chemical. BPA interacts not only with oestrogen receptors (ERs) but constitutive androstane receptor, preg...
Autores principales: | Masuya, Takahiro, Iwamoto, Masaki, Liu, Xiaohui, Matsushima, Ayami |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616570/ https://www.ncbi.nlm.nih.gov/pubmed/31289329 http://dx.doi.org/10.1038/s41598-019-46272-y |
Ejemplares similares
-
Bisphenol AF Is a Full Agonist for the Estrogen Receptor ERα but a Highly Specific Antagonist for ERβ
por: Matsushima, Ayami, et al.
Publicado: (2010) -
Oestrogen-mediated cardioprotection following ischaemia and reperfusion is mimicked by an oestrogen receptor (ER)α agonist and unaffected by an ERβ antagonist
por: Jeanes, Helen L, et al.
Publicado: (2008) -
Privileged Structures Revisited
por: Schneider, Petra, et al.
Publicado: (2017) -
Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor β
por: Iwamoto, Masaki, et al.
Publicado: (2021) -
Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery
por: Khwaza, Vuyolwethu, et al.
Publicado: (2021)