Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer

Endocrine therapy (ET) is the standard of care for estrogen receptor-positive (ER(+)) breast cancers. Despite its efficacy, ∼40% of women relapse with ET-resistant (ETR) disease. A global transcription analysis in ETR cells reveals a downregulation of the neutral and basic amino acid transporter SLC...

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Detalles Bibliográficos
Autores principales: Bacci, Marina, Lorito, Nicla, Ippolito, Luigi, Ramazzotti, Matteo, Luti, Simone, Romagnoli, Simone, Parri, Matteo, Bianchini, Francesca, Cappellesso, Federica, Virga, Federico, Gao, Qiong, Simões, Bruno M., Marangoni, Elisabetta, Martin, Lesley-Ann, Comito, Giuseppina, Ferracin, Manuela, Giannoni, Elisa, Mazzone, Massimiliano, Chiarugi, Paola, Morandi, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616584/
https://www.ncbi.nlm.nih.gov/pubmed/31269432
http://dx.doi.org/10.1016/j.celrep.2019.06.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616584/
https://www.ncbi.nlm.nih.gov/pubmed/31269432
http://dx.doi.org/10.1016/j.celrep.2019.06.010

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