Simvastatin Attenuates Cardiac Fibrosis via Regulation of Cardiomyocyte-Derived Exosome Secretion

Exosome-mediated communication within the cardiac microenvironment is associated with cardiac fibrosis. Simvastatin (SIM), a potent statin, protects against cardiac fibrosis, but its mechanism of action is unclear. We investigated the inhibitory effects and underlying mechanism of simvastatin in car...

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Detalles Bibliográficos
Autores principales: Kuo, Hsuan-Fu, Hsieh, Chong-Chao, Wang, Shu-Chi, Chang, Chia-Yuan, Hung, Chih-Hsin, Kuo, Po-Lin, Liu, Yu-Ru, Li, Chia-Yang, Liu, Po-Len
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617127/
https://www.ncbi.nlm.nih.gov/pubmed/31167519
http://dx.doi.org/10.3390/jcm8060794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617127/
https://www.ncbi.nlm.nih.gov/pubmed/31167519
http://dx.doi.org/10.3390/jcm8060794

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