In-Vivo Degradation of DNA-Based Therapeutic BC 007 in Humans

BACKGROUND AND OBJECTIVES: Since there is no clear evidence in the literature to show how non-modified single-stranded DNA (ssDNA) drugs are metabolized in humans, we assessed the metabolism of BC 007, an ssDNA therapeutic, under development as a neutralizer of autoantibodies against G-protein-coupl...

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Detalles Bibliográficos
Autores principales: Davideit, Hanna, Becker, Susanne, Müller, Johannes, Becker, Niels-Peter, Göttel, Peter, Abay, Ayşe, Sinn, Angela, Grossmann, Matthias, Mallek, Markus, Haberland, Annekathrin, Weisshoff, Hardy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617257/
https://www.ncbi.nlm.nih.gov/pubmed/30674038
http://dx.doi.org/10.1007/s13318-019-00541-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617257/
https://www.ncbi.nlm.nih.gov/pubmed/30674038
http://dx.doi.org/10.1007/s13318-019-00541-3

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