Cargando…

In-Vivo Degradation of DNA-Based Therapeutic BC 007 in Humans

BACKGROUND AND OBJECTIVES: Since there is no clear evidence in the literature to show how non-modified single-stranded DNA (ssDNA) drugs are metabolized in humans, we assessed the metabolism of BC 007, an ssDNA therapeutic, under development as a neutralizer of autoantibodies against G-protein-coupl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Davideit, Hanna, Becker, Susanne, Müller, Johannes, Becker, Niels-Peter, Göttel, Peter, Abay, Ayşe, Sinn, Angela, Grossmann, Matthias, Mallek, Markus, Haberland, Annekathrin, Weisshoff, Hardy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2019
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617257/ https://www.ncbi.nlm.nih.gov/pubmed/30674038 http://dx.doi.org/10.1007/s13318-019-00541-3

Ejemplares similares

Aptamer BC 007 - Efficient binder of spreading-crucial SARS-CoV-2 proteins
por: Weisshoff, Hardy, et al.
Publicado: (2020)

Aptamer BC 007’s Affinity to Specific and Less-Specific Anti-SARS-CoV-2 Neutralizing Antibodies
por: Haberland, Annekathrin, et al.
Publicado: (2021)

A Three-Part, Randomised Study to Investigate the Safety, Tolerability, Pharmacokinetics and Mode of Action of BC 007, Neutraliser of Pathogenic Autoantibodies Against G-Protein Coupled Receptors in Healthy, Young and Elderly Subjects
por: Becker, Niels-Peter, et al.
Publicado: (2020)

The aptamer BC 007 for treatment of dilated cardiomyopathy: evaluation in Doberman Pinschers of efficacy and outcomes
por: Werner, Sabine, et al.
Publicado: (2020)

Performance and in-house validation of a bioassay for the determination of beta1-autoantibodies found in patients with cardiomyopathy
por: Wenzel, Katrin, et al.
Publicado: (2017)

Lack of efficacy of mono‐mode of action therapeutics in COVID‐19 therapy ‐ How the lack of predictive power of preclinical cell and animal studies leads developments astray
por: Haberland, Annekathrin, et al.
Publicado: (2021)

Aptamers Against COVID-19: An Untested Opportunity
por: Haberland, Annekathrin, et al.
Publicado: (2022)

Activation of T Lymphocytes as a Novel Mechanism in Beta1-Adrenergic Receptor Autoantibody-Induced Cardiac Remodeling—Additional Information About TLR9 Involvement
por: Haberland, Annekathrin, et al.
Publicado: (2019)

Antigen-free control wells in an ELISA set-up for the determination of autoantibodies against G protein-coupled receptors—a requisite for correct data evaluation
por: Haberland, Annekathrin, et al.
Publicado: (2018)

Autoantibodies directed against α1-adrenergic receptor and endothelin receptor A in patients with prostate cancer
por: Wallukat, Gerd, et al.
Publicado: (2020)

Difference between beta1-adrenoceptor autoantibodies of human and animal origin—Limitations detecting beta1-adrenoceptor autoantibodies using peptide based ELISA technology
por: Wenzel, Katrin, et al.
Publicado: (2018)

Fractionation of Extracts from Black Chokeberry, Cranberry, and Pomegranate to Identify Compounds That Influence Lipid Metabolism
por: Niesen, Sonja, et al.
Publicado: (2022)

CompTIA network+ N10-007
por: Dulaney, Emmet
Publicado: (2018)

Title unknown, CERN-ALEPH-2001-007
por: CERN. Geneva. ALEPH
Publicado: (2001)

AVC amplifier plug in 490-007 LE
por: Barthélémy, R, et al.
Publicado: (1983)

AB007. Testosterone and radiotherapy for prostate cancer
por: Incrocci, Luca
Publicado: (2015)

Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection
por: Hohberger, Bettina, et al.
Publicado: (2021)

Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy?
por: Haberland, Annekathrin, et al.
Publicado: (2013)

Genome sequence of Ochrobactrum anthropi strain SUBG007, a plant pathogen and potential xenobiotic compounds degradation bacterium
por: Chudasama, Kiran S., et al.
Publicado: (2017)

Track reconstruction in the ATLAS Muon Spectrometer with MOORE 007
por: Adams, D, et al.
Publicado: (2003)

Determination of the z position of primary interactions in ATLAS 007
por: Konstantinidis, N P, et al.
Publicado: (2002)

Sequence and annotation of the Wizard007 mycobacterium phage genome
por: Anyanwu, Ejike, et al.
Publicado: (2010)

P02-007 - Childhood autoinflammatory disorders in Qatar
por: Aladbe, B, et al.
Publicado: (2013)

Genome Sequences of Mycobacteriophages Findley, Hurricane, and TBond007
por: Saha, Sanghamitra, et al.
Publicado: (2017)

PSAT007 Pheochromocytoma Presenting With Small Bowel Obstruction
por: Devine, Alma, et al.
Publicado: (2022)

CompTIA Network+ N10-007 cert guide
por: Sequeira, Anthony
Publicado: (2018)

PARTNERSHIP AGREEMENT K1496/TT/AB/007P
por: THE EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH, CERN, et al.
Publicado: (2008)

Comptia Network+ practice tests: exam N10-007
por: Zacker, Craig
Publicado: (2018)

Comptia Network+ review guide: exam N10-007
por: Buhagiar, Jon
Publicado: (2018)

P03-007 - Mevalonate kinase gene in Behçet’s disease
por: Tas, D Arslan, et al.
Publicado: (2013)

P01-007 – Evaluation of potential risk factors of Amyloidosis
por: Kasifoglu, T, et al.
Publicado: (2013)

PW01-007 – Colchicine brand switching in FMF patients
por: Jagger, J, et al.
Publicado: (2013)

PW02-007 - The Eurofever registry: 3 years of enrollment
por: Federici, S, et al.
Publicado: (2013)

O007. Self-referred cognitive impairment in migraine patients
por: Costa, Amerigo, et al.
Publicado: (2015)

Studies of the properties and decays of the $B_c^+$ meson at LHCb
por: Tuning, Niels
Publicado: (2013)

Photocatalytic Degradation and Toxicity Analysis of Sulfamethoxazole using TiO(2)/BC
por: Dang, Jiatao, et al.
Publicado: (2023)

Bacterial Cellulose (BC) and BC Composites: Production and Properties
por: Volova, Tatiana G., et al.
Publicado: (2022)

Synthesis, Structure, and Spectroscopy of the Biscarboranyl Stannylenes (bc)Sn·THF and K(2)[(bc)Sn](2) (bc = 1,1′(ortho-Biscarborane)) and Dibiscarboranyl Ethene (bc)CH=CH(bc)
por: Phung, Alice C., et al.
Publicado: (2023)

The Value of Serum Biomarkers (Bc1, Bc2, Bc3) in the Diagnosis of Early Breast Cancer
por: Atahan, Kemal, et al.
Publicado: (2011)

Correction to “Synthesis, Structure, and Spectroscopy of the Biscarboranyl Stannylenes (bc)Sn·THF and K(2)[(bc)Sn](2) (bc = 1,1′(ortho-Biscarborane)) and Dibiscarboranyl Ethene (bc)CH=CH(bc)”
por: Phung, Alice C., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_26uop5vcfq9g75r873t7on2j8t