Propofol attenuated TNF-α-modulated occludin expression by inhibiting Hif-1α/ VEGF/ VEGFR-2/ ERK signaling pathway in hCMEC/D3 cells

BACKGROUND: The levels of tight junction proteins (TJs), especially occludin, correlate with blood-brain barrier (BBB) disruption caused by inflammation in central nervous system (CNS). It has been reported that propofol, the most commonly used anesthetic, could inhibit inflammation response in CNS....

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Detalles Bibliográficos
Autores principales: Zhang, Yue, Ding, Xiaowei, Miao, Changhong, Chen, Jiawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617648/
https://www.ncbi.nlm.nih.gov/pubmed/31288745
http://dx.doi.org/10.1186/s12871-019-0788-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617648/
https://www.ncbi.nlm.nih.gov/pubmed/31288745
http://dx.doi.org/10.1186/s12871-019-0788-5

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