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Propofol attenuated TNF-α-modulated occludin expression by inhibiting Hif-1α/ VEGF/ VEGFR-2/ ERK signaling pathway in hCMEC/D3 cells
BACKGROUND: The levels of tight junction proteins (TJs), especially occludin, correlate with blood-brain barrier (BBB) disruption caused by inflammation in central nervous system (CNS). It has been reported that propofol, the most commonly used anesthetic, could inhibit inflammation response in CNS....
Autores principales: | Zhang, Yue, Ding, Xiaowei, Miao, Changhong, Chen, Jiawei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617648/ https://www.ncbi.nlm.nih.gov/pubmed/31288745 http://dx.doi.org/10.1186/s12871-019-0788-5 |
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