Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb

BACKGROUND: Nothapodytes nimmoniana, a plant of pivotal medicinal significance is a source of potent anticancer monoterpene indole alkaloid (MIA) camptothecin (CPT). This compound owes its potency due to topoisomerase-I inhibitory activity. However, biosynthetic and regulatory aspects of CPT biosynt...

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Detalles Bibliográficos
Autores principales: Rather, Gulzar A., Sharma, Arti, Jeelani, Syed Mudassir, Misra, Prashant, Kaul, Veenu, Lattoo, Surrinder K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617690/
https://www.ncbi.nlm.nih.gov/pubmed/31291885
http://dx.doi.org/10.1186/s12870-019-1912-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617690/
https://www.ncbi.nlm.nih.gov/pubmed/31291885
http://dx.doi.org/10.1186/s12870-019-1912-x

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