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Apolipoprotein E associated with reconstituted high‐density lipoprotein‐like particles is protected from aggregation

Apolipoprotein E (APOE) genotype determines Alzheimer's disease (AD) susceptibility, with the APOE ε4 allele being an established risk factor for late‐onset AD. The ApoE lipidation status has been reported to impact amyloid‐beta (Aβ) peptide metabolism. The details of how lipidation affects Apo...

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Detalles Bibliográficos
Autores principales: Hubin, Ellen, Verghese, Philip B., van Nuland, Nico, Broersen, Kerensa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617784/
https://www.ncbi.nlm.nih.gov/pubmed/31058310
http://dx.doi.org/10.1002/1873-3468.13428