Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities

BACKGROUND: Dynactin subunit 1 is the largest subunit of the dynactin complex, an activator of the molecular motor protein complex dynein. Reduced levels of DCTN1 mRNA and protein have been found in sporadic amyotrophic lateral sclerosis (ALS) patients, and mutations have been associated with diseas...

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Detalles Bibliográficos
Autores principales: Bercier, Valérie, Hubbard, Jeffrey M., Fidelin, Kevin, Duroure, Karine, Auer, Thomas O., Revenu, Céline, Wyart, Claire, Del Bene, Filippo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617949/
https://www.ncbi.nlm.nih.gov/pubmed/31291987
http://dx.doi.org/10.1186/s13024-019-0327-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617949/
https://www.ncbi.nlm.nih.gov/pubmed/31291987
http://dx.doi.org/10.1186/s13024-019-0327-3

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