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Peripheral IgE Repertoires of Healthy Donors Carry Moderate Mutation Loads and Do Not Overlap With Other Isotypes

IgE-mediated allergic disease represents an increasing health problem. Although numerous studies have investigated IgE sequences in allergic patients, little information is available on the healthy IgE repertoire. IgM, IgG, IgA, and IgE transcripts from peripheral blood B cells of five healthy, non-...

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Detalles Bibliográficos
Autores principales: Koning, Marvyn T., Trollmann, Ignis J. M., van Bergen, Cornelis A. M., Alvarez Saravia, Diego, Navarrete, Marcelo A., Kiełbasa, Szymon M., Veelken, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617986/
https://www.ncbi.nlm.nih.gov/pubmed/31333671
http://dx.doi.org/10.3389/fimmu.2019.01543