Cargando…

Tumor mutational burden standardization initiatives: Recommendations for consistent tumor mutational burden assessment in clinical samples to guide immunotherapy treatment decisions

Characterization of tumors utilizing next‐generation sequencing methods, including assessment of the number of somatic mutations (tumor mutational burden [TMB]), is currently at the forefront of the field of personalized medicine. Recent clinical studies have associated high TMB with improved patien...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stenzinger, Albrecht, Allen, Jeffrey D., Maas, Jörg, Stewart, Mark D., Merino, Diana M., Wempe, Madison M., Dietel, Manfred
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618007/ https://www.ncbi.nlm.nih.gov/pubmed/30664300 http://dx.doi.org/10.1002/gcc.22733

Ejemplares similares

Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic
por: Chan, T A, et al.
Publicado: (2019)

Beyond Tumor Mutation Burden: Tumor Neoantigen Burden as a Biomarker for Immunotherapy and Other Types of Therapy
por: Wang, Peipei, et al.
Publicado: (2021)

MHC-I genotype and tumor mutational burden predict response to immunotherapy
por: Goodman, Aaron M., et al.
Publicado: (2020)

Role of ultraviolet mutational signature versus tumor mutation burden in predicting response to immunotherapy
por: Pham, Timothy V., et al.
Publicado: (2020)

Tumor mutational burden as a predictor of immunotherapy response in breast cancer
por: O’Meara, Tess A., et al.
Publicado: (2021)

Challenges in bioinformatics approaches to tumor mutation burden analysis
por: Fenizia, Francesca, et al.
Publicado: (2021)

Racial disparities in patient survival and tumor mutation burden, and the association between tumor mutation burden and cancer incidence rate
por: Zhang, Wensheng, et al.
Publicado: (2017)

Favorable response to immunotherapy in a pancreatic neuroendocrine tumor with temozolomide‐induced high tumor mutational burden
por: Cao, Yanshuo, et al.
Publicado: (2020)

Clinical sequencing to assess tumor mutational burden as a useful biomarker to immunotherapy in various solid tumors
por: Kim, Hana, et al.
Publicado: (2021)

Tumor mutation burden: from comprehensive mutational screening to the clinic
por: Galuppini, Francesca, et al.
Publicado: (2019)

Assessment of Tumor Mutational Burden and Outcomes in Patients With Diverse Advanced Cancers Treated With Immunotherapy
por: Aggarwal, Charu, et al.
Publicado: (2023)

Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms: phase I of the Friends of Cancer Research TMB Harmonization Project
por: Merino, Diana M, et al.
Publicado: (2020)

The Clinical Implications of Tumor Mutational Burden in Osteosarcoma
por: Xie, Lu, et al.
Publicado: (2021)

Tumor mutation burden and recurrent tumors in hereditary lung cancer
por: Hsu, Yi‐Chiung, et al.
Publicado: (2019)

Tumor-mutation burden as a marker for immunotherapy of pancreatic cancer: the case report and literature review
por: Zhu, Peng-Fei, et al.
Publicado: (2021)

Immune Determinants of the Association between Tumor Mutational Burden and Immunotherapy Response across Cancer Types
por: Sinha, Neelam, et al.
Publicado: (2022)

SETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapy
por: Zheng, Xiaobin, et al.
Publicado: (2023)

Tumor mutational burden is not predictive of cytotoxic chemotherapy response
por: Nikanjam, Mina, et al.
Publicado: (2020)

Effect of prior therapy on tumor mutational burden in NSCLC
por: Jonna, Sushma, et al.
Publicado: (2021)

Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds
por: Alsaihati, Burair A., et al.
Publicado: (2021)

Characterization of tumors with ultralow tumor mutational burden in Japanese cancer patients
por: Hatakeyama, Keiichi, et al.
Publicado: (2020)

Panels and models for accurate prediction of tumor mutation burden in tumor samples
por: Martínez-Pérez, Elizabeth, et al.
Publicado: (2021)

Significance of tumor mutation burden and immune infiltration in thymic epithelial tumors
por: Wang, Zi‐Ming, et al.
Publicado: (2021)

Novel tumor mutation score versus tumor mutation burden in predicting survival after immunotherapy in pan-cancer patients from the MSK-IMPACT cohort
por: Li, Yuan, et al.
Publicado: (2020)

Spontaneous mutations in the single TTN gene represent high tumor mutation burden
por: Oh, Ji-Hye, et al.
Publicado: (2020)

Biomarkers of immunotherapy in urothelial and renal cell carcinoma: PD-L1, tumor mutational burden, and beyond
por: Zhu, Jason, et al.
Publicado: (2018)

Burden of tumor mutations, neoepitopes, and other variants are weak predictors of cancer immunotherapy response and overall survival
por: Wood, Mary A., et al.
Publicado: (2020)

Case Report: Sequential Chemotherapy and Immunotherapy Produce Sustained Response in Osteosarcoma With High Tumor Mutational Burden
por: Zheng, Shuier, et al.
Publicado: (2021)

Inflation of tumor mutation burden by tumor-only sequencing in under-represented groups
por: Asmann, Yan W., et al.
Publicado: (2021)

Tumor mutational burden in lung cancer: a systematic literature review
por: Willis, Connor, et al.
Publicado: (2019)

Correlate tumor mutation burden with immune signatures in human cancers
por: Wang, Xiaosheng, et al.
Publicado: (2019)

Tumor mutational burden is associated with poor outcomes in diffuse glioma
por: Wang, Lihong, et al.
Publicado: (2020)

Analysis of Threshold Change of Tumor Mutation Burden in Gastric Cancer
por: He, Xinwei, et al.
Publicado: (2021)

Multiomics analysis of tumor mutational burden across cancer types
por: Li, Lin, et al.
Publicado: (2021)

Tumor Mutational Burden Associated With Response to Hyperthermic Intraperitoneal Chemotherapy
por: Zeng, Lisi, et al.
Publicado: (2022)

Characteristics of Pan-Cancer Patients With Ultrahigh Tumor Mutation Burden
por: Yuan, Hong, et al.
Publicado: (2021)

Genomic Alterations and Tumor Mutation Burden in Merkel Cell Carcinoma
por: Brazel, Danielle, et al.
Publicado: (2023)

Characterization of pancreatic cancer with ultra-low tumor mutational burden
por: Imamura, Taisuke, et al.
Publicado: (2023)

Development and validation of blood tumor mutational burden reference standards
por: Raiber‐Moreau, Eun‐Ang, et al.
Publicado: (2022)

Tumor mutation burden in gastro-entero-pancreatic-neuroendocrine neoplasms
por: Jeong, Sun Young, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8phleh06f0of564gcv2cs1jmu9