Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation

Quaternized vinyl‐ and alkynyl‐pyridine reagents were shown to react in an ultrafast and selective manner with several cysteine‐tagged proteins at near‐stoichiometric quantities. We have demonstrated that this method can effectively create a homogenous antibody–drug conjugate that features a precise...

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Detalles Bibliográficos
Autores principales: Matos, Maria J., Navo, Claudio D., Hakala, Tuuli, Ferhati, Xhenti, Guerreiro, Ana, Hartmann, David, Bernardim, Barbara, Saar, Kadi L., Compañón, Ismael, Corzana, Francisco, Knowles, Tuomas P. J., Jiménez‐Osés, Gonzalo, Bernardes, Gonçalo J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618083/
https://www.ncbi.nlm.nih.gov/pubmed/30897271
http://dx.doi.org/10.1002/anie.201901405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618083/
https://www.ncbi.nlm.nih.gov/pubmed/30897271
http://dx.doi.org/10.1002/anie.201901405

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