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Astrocyte‐specific deletion of the mitochondrial m‐AAA protease reveals glial contribution to neurodegeneration

Mitochondrial dysfunction causes neurodegeneration but whether impairment of mitochondrial homeostasis in astrocytes contributes to this pathological process remains largely unknown. The m‐AAA protease exerts quality control and regulatory functions crucial for mitochondrial homeostasis. AFG3L2, whi...

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Detalles Bibliográficos
Autores principales: Murru, Sara, Hess, Simon, Barth, Esther, Almajan, Eva R., Schatton, Désirée, Hermans, Steffen, Brodesser, Susanne, Langer, Thomas, Kloppenburg, Peter, Rugarli, Elena I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618114/
https://www.ncbi.nlm.nih.gov/pubmed/30989755
http://dx.doi.org/10.1002/glia.23626