Integrated In Vivo Genotoxicity Assessment of Procarbazine Hydrochloride Demonstrates Induction of Pig‐a and LacZ Mutations, and Micronuclei, in MutaMouse Hematopoietic Cells

Procarbazine hydrochloride (PCH) is a DNA‐reactive hematopoietic carcinogen with potent and well‐characterized clastogenic activity. However, there is a paucity of in vivo mutagenesis data for PCH, and in vitro assays often fail to detect the genotoxic effects of PCH due to the complexity of its met...

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Detalles Bibliográficos
Autores principales: Maurice, Clotilde, Dertinger, Stephen D., Yauk, Carole L., Marchetti, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618172/
https://www.ncbi.nlm.nih.gov/pubmed/30592561
http://dx.doi.org/10.1002/em.22271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618172/
https://www.ncbi.nlm.nih.gov/pubmed/30592561
http://dx.doi.org/10.1002/em.22271

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