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Role of microRNAs in stroke recovery
Ischemic stroke is an important cause of morbidity and mortality across the globe. It is associated with physical, social, and economic disability. Immediately after the stroke, there is a critical period of spontaneous recovery during which there is maximal return to near normal. Following stroke,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618220/ https://www.ncbi.nlm.nih.gov/pubmed/31334144 http://dx.doi.org/10.4103/jfmpc.jfmpc_296_19 |
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author | Bansal, Agam Prathap, Rana Gupta, Samiksha Chaurasia, Aditi Chaudhary, Pooja |
author_facet | Bansal, Agam Prathap, Rana Gupta, Samiksha Chaurasia, Aditi Chaudhary, Pooja |
author_sort | Bansal, Agam |
collection | PubMed |
description | Ischemic stroke is an important cause of morbidity and mortality across the globe. It is associated with physical, social, and economic disability. Immediately after the stroke, there is a critical period of spontaneous recovery during which there is maximal return to near normal. Following stroke, there is a period of neurogenesis, angiogenesis, axonal growth, and synaptic plasticity. There have been several studies focusing on neuroprotection and enhancing recovery following stroke. However, translation of these into clinical practice has been disappointing. The role of microRNAs in treatment of cancer has been well documented, but studying their role in stroke recovery has been minimal. MicroRNAs serve as critical mediators of recovery following stroke. In this review article, we discuss the role of microRNAs in stroke recovery. |
format | Online Article Text |
id | pubmed-6618220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-66182202019-07-22 Role of microRNAs in stroke recovery Bansal, Agam Prathap, Rana Gupta, Samiksha Chaurasia, Aditi Chaudhary, Pooja J Family Med Prim Care Review Article Ischemic stroke is an important cause of morbidity and mortality across the globe. It is associated with physical, social, and economic disability. Immediately after the stroke, there is a critical period of spontaneous recovery during which there is maximal return to near normal. Following stroke, there is a period of neurogenesis, angiogenesis, axonal growth, and synaptic plasticity. There have been several studies focusing on neuroprotection and enhancing recovery following stroke. However, translation of these into clinical practice has been disappointing. The role of microRNAs in treatment of cancer has been well documented, but studying their role in stroke recovery has been minimal. MicroRNAs serve as critical mediators of recovery following stroke. In this review article, we discuss the role of microRNAs in stroke recovery. Wolters Kluwer - Medknow 2019-06 /pmc/articles/PMC6618220/ /pubmed/31334144 http://dx.doi.org/10.4103/jfmpc.jfmpc_296_19 Text en Copyright: © 2019 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Bansal, Agam Prathap, Rana Gupta, Samiksha Chaurasia, Aditi Chaudhary, Pooja Role of microRNAs in stroke recovery |
title | Role of microRNAs in stroke recovery |
title_full | Role of microRNAs in stroke recovery |
title_fullStr | Role of microRNAs in stroke recovery |
title_full_unstemmed | Role of microRNAs in stroke recovery |
title_short | Role of microRNAs in stroke recovery |
title_sort | role of micrornas in stroke recovery |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618220/ https://www.ncbi.nlm.nih.gov/pubmed/31334144 http://dx.doi.org/10.4103/jfmpc.jfmpc_296_19 |
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