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Role of microRNAs in stroke recovery

Ischemic stroke is an important cause of morbidity and mortality across the globe. It is associated with physical, social, and economic disability. Immediately after the stroke, there is a critical period of spontaneous recovery during which there is maximal return to near normal. Following stroke,...

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Autores principales: Bansal, Agam, Prathap, Rana, Gupta, Samiksha, Chaurasia, Aditi, Chaudhary, Pooja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618220/
https://www.ncbi.nlm.nih.gov/pubmed/31334144
http://dx.doi.org/10.4103/jfmpc.jfmpc_296_19
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author Bansal, Agam
Prathap, Rana
Gupta, Samiksha
Chaurasia, Aditi
Chaudhary, Pooja
author_facet Bansal, Agam
Prathap, Rana
Gupta, Samiksha
Chaurasia, Aditi
Chaudhary, Pooja
author_sort Bansal, Agam
collection PubMed
description Ischemic stroke is an important cause of morbidity and mortality across the globe. It is associated with physical, social, and economic disability. Immediately after the stroke, there is a critical period of spontaneous recovery during which there is maximal return to near normal. Following stroke, there is a period of neurogenesis, angiogenesis, axonal growth, and synaptic plasticity. There have been several studies focusing on neuroprotection and enhancing recovery following stroke. However, translation of these into clinical practice has been disappointing. The role of microRNAs in treatment of cancer has been well documented, but studying their role in stroke recovery has been minimal. MicroRNAs serve as critical mediators of recovery following stroke. In this review article, we discuss the role of microRNAs in stroke recovery.
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spelling pubmed-66182202019-07-22 Role of microRNAs in stroke recovery Bansal, Agam Prathap, Rana Gupta, Samiksha Chaurasia, Aditi Chaudhary, Pooja J Family Med Prim Care Review Article Ischemic stroke is an important cause of morbidity and mortality across the globe. It is associated with physical, social, and economic disability. Immediately after the stroke, there is a critical period of spontaneous recovery during which there is maximal return to near normal. Following stroke, there is a period of neurogenesis, angiogenesis, axonal growth, and synaptic plasticity. There have been several studies focusing on neuroprotection and enhancing recovery following stroke. However, translation of these into clinical practice has been disappointing. The role of microRNAs in treatment of cancer has been well documented, but studying their role in stroke recovery has been minimal. MicroRNAs serve as critical mediators of recovery following stroke. In this review article, we discuss the role of microRNAs in stroke recovery. Wolters Kluwer - Medknow 2019-06 /pmc/articles/PMC6618220/ /pubmed/31334144 http://dx.doi.org/10.4103/jfmpc.jfmpc_296_19 Text en Copyright: © 2019 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Bansal, Agam
Prathap, Rana
Gupta, Samiksha
Chaurasia, Aditi
Chaudhary, Pooja
Role of microRNAs in stroke recovery
title Role of microRNAs in stroke recovery
title_full Role of microRNAs in stroke recovery
title_fullStr Role of microRNAs in stroke recovery
title_full_unstemmed Role of microRNAs in stroke recovery
title_short Role of microRNAs in stroke recovery
title_sort role of micrornas in stroke recovery
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618220/
https://www.ncbi.nlm.nih.gov/pubmed/31334144
http://dx.doi.org/10.4103/jfmpc.jfmpc_296_19
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