PMS2 expression decrease causes severe problems in mismatch repair

PMS2 is one of the four susceptibility genes in Lynch syndrome (LS), the most common cancer syndrome in the world. Inherited mutations in DNA mismatch repair (MMR) genes, MLH1, MSH2, and MSH6, account for approximately 90% of LS, while a relatively small number of LS families segregate a PMS2 mutati...

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Detalles Bibliográficos
Autores principales: Kasela, Mariann, Nyström, Minna, Kansikas, Minttu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618857/
https://www.ncbi.nlm.nih.gov/pubmed/30946512
http://dx.doi.org/10.1002/humu.23756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618857/
https://www.ncbi.nlm.nih.gov/pubmed/30946512
http://dx.doi.org/10.1002/humu.23756

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