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PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism
Insulin stimulates the conversion of phosphatidylino-sitol-4,5-bisphosphate (PI(4,5)P(2)) to phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P(3)), which mediates downstream cellular responses. PI(4,5)P(2) is produced by phosphatidylinositol-4-phosphate 5-kinases (PIP5Ks) and by phosphatidylinosi...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619495/ https://www.ncbi.nlm.nih.gov/pubmed/31091439 http://dx.doi.org/10.1016/j.celrep.2019.04.070 |