PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism

Insulin stimulates the conversion of phosphatidylino-sitol-4,5-bisphosphate (PI(4,5)P(2)) to phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P(3)), which mediates downstream cellular responses. PI(4,5)P(2) is produced by phosphatidylinositol-4-phosphate 5-kinases (PIP5Ks) and by phosphatidylinosi...

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Detalles Bibliográficos
Autores principales: Wang, Diana G., Paddock, Marcia N., Lundquist, Mark R., Sun, Janet Y., Mashadova, Oksana, Amadiume, Solomon, Bumpus, Timothy W., Hodakoski, Cindy, Hopkins, Benjamin D., Fine, Matthew, Hill, Amanda, Yang, T. Jonathan, Baskin, Jeremy M., Dow, Lukas E., Cantley, Lewis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619495/
https://www.ncbi.nlm.nih.gov/pubmed/31091439
http://dx.doi.org/10.1016/j.celrep.2019.04.070

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