Oncogenic LncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

The mechanisms through which tumor cells genetically lose antigenicity and evade immune checkpoints remain largely elusive. Here, we report that tissue-specific expression of the human long-noncoding RNA LINK-A in mouse mammary glands initiated metastatic mammary gland tumors, which phenotypically r...

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Detalles Bibliográficos
Autores principales: Hu, Qingsong, Ye, Youqiong, Chan, Li-Chuan, Li, Yajuan, Liang, Ke, Lin, Aifu, Egranov, Sergey D., Zhang, Yaohua, Xia, Weiya, Gong, Jing, Pan, Yinghong, Chatterjee, Sujash S., Yao, Jun, Evans, Kurt W., Nguyen, Tina K., Park, Peter K., Liu, Jiewei, Coarfa, Cristian, Donepudi, Sri Ramya, Putluri, Vasanta, Putluri, Nagireddy, Sreekumar, Arun, Ambati, Chandrashekar R., Hawke, David H., Marks, Jeffrey R., Gunaratne, Preethi H., Caudle, Abigail S., Sahin, Aysegul A., Hortobagyi, Gabriel N., Meric-Bernstam, Funda, Chen, Lieping, Yu, Dihua, Hung, Mien-Chie, Curran, Michael A., Han, Leng, Lin, Chunru, Yang, Liuqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619502/
https://www.ncbi.nlm.nih.gov/pubmed/31160797
http://dx.doi.org/10.1038/s41590-019-0400-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619502/
https://www.ncbi.nlm.nih.gov/pubmed/31160797
http://dx.doi.org/10.1038/s41590-019-0400-7

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