Structure of the DNA-Bound Spacer Capture Complex of a Type II CRISPR-Cas System

CRISPR and associated Cas proteins function as an adaptive immune system in prokaryotes to combat bacteriophage infection. During the immunization step, new spacers are acquired by the CRISPR machinery, but the molecular mechanism of spacer capture remains enigmatic. We show that the Cas9, Cas1, Cas...

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Detalles Bibliográficos
Autores principales: Wilkinson, Martin, Drabavicius, Gediminas, Silanskas, Arunas, Gasiunas, Giedrius, Siksnys, Virginijus, Wigley, Dale B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620040/
https://www.ncbi.nlm.nih.gov/pubmed/31080012
http://dx.doi.org/10.1016/j.molcel.2019.04.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620040/
https://www.ncbi.nlm.nih.gov/pubmed/31080012
http://dx.doi.org/10.1016/j.molcel.2019.04.020

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