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Structure of the DNA-Bound Spacer Capture Complex of a Type II CRISPR-Cas System
CRISPR and associated Cas proteins function as an adaptive immune system in prokaryotes to combat bacteriophage infection. During the immunization step, new spacers are acquired by the CRISPR machinery, but the molecular mechanism of spacer capture remains enigmatic. We show that the Cas9, Cas1, Cas...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620040/ https://www.ncbi.nlm.nih.gov/pubmed/31080012 http://dx.doi.org/10.1016/j.molcel.2019.04.020 |