Cellular response to moderate chromatin architectural defects promotes longevity

Changes in chromatin organization occur during aging. Overexpression of histones partially alleviates these changes and promotes longevity. We report that deletion of the histone H3-H4 minor locus HHT1-HHF1 extended the replicative life span of Saccharomyces cerevisiae. This longevity effect was med...

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Detalles Bibliográficos
Autores principales: Yu, Ruofan, Sun, Luyang, Sun, Yu, Han, Xin, Qin, Lidong, Dang, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620092/
https://www.ncbi.nlm.nih.gov/pubmed/31309140
http://dx.doi.org/10.1126/sciadv.aav1165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620092/
https://www.ncbi.nlm.nih.gov/pubmed/31309140
http://dx.doi.org/10.1126/sciadv.aav1165

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