Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML

The key myeloid transcription factor (TF), CEBPA, is frequently mutated in acute myeloid leukemia (AML), but the direct molecular effects of this leukemic driver mutation remain elusive. To investigate CEBPA mutant AML, we performed microscale, in vivo chromatin immunoprecipitation sequencing and id...

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Detalles Bibliográficos
Autores principales: Jakobsen, Janus S., Laursen, Linea G., Schuster, Mikkel B., Pundhir, Sachin, Schoof, Erwin, Ge, Ying, d’Altri, Teresa, Vitting-Seerup, Kristoffer, Rapin, Nicolas, Gentil, Coline, Jendholm, Johan, Theilgaard-Mönch, Kim, Reckzeh, Kristian, Bullinger, Lars, Döhner, Konstanze, Hokland, Peter, Fitzgibbon, Jude, Porse, Bo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620102/
https://www.ncbi.nlm.nih.gov/pubmed/31309149
http://dx.doi.org/10.1126/sciadv.aaw4304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620102/
https://www.ncbi.nlm.nih.gov/pubmed/31309149
http://dx.doi.org/10.1126/sciadv.aaw4304

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