Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome

Mycobacterium tuberculosis readily adapts to survive a wide range of assaults by modifying its physiology and establishing a latent tuberculosis (TB) infection. Here we report a sophisticated mode of regulation by a tRNA-cleaving toxin that enlists highly selective ribosome stalling to recalibrate t...

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Detalles Bibliográficos
Autores principales: Barth, Valdir C., Zeng, Ju-Mei, Vvedenskaya, Irina O., Ouyang, Ming, Husson, Robert N., Woychik, Nancy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620280/
https://www.ncbi.nlm.nih.gov/pubmed/31292443
http://dx.doi.org/10.1038/s41467-019-10869-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620280/
https://www.ncbi.nlm.nih.gov/pubmed/31292443
http://dx.doi.org/10.1038/s41467-019-10869-8

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