Disease-causing mutations in subunits of OXPHOS complex I affect certain physical interactions

Mitochondrial complex I (CI) is the largest multi-subunit oxidative phosphorylation (OXPHOS) protein complex. Recent availability of a high-resolution human CI structure, and from two non-human mammals, enabled predicting the impact of mutations on interactions involving each of the 44 CI subunits....

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Detalles Bibliográficos
Autores principales: Barshad, Gilad, Zlotnikov-Poznianski, Nicol, Gal, Lihi, Schuldiner, Maya, Mishmar, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620328/
https://www.ncbi.nlm.nih.gov/pubmed/31292494
http://dx.doi.org/10.1038/s41598-019-46446-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620328/
https://www.ncbi.nlm.nih.gov/pubmed/31292494
http://dx.doi.org/10.1038/s41598-019-46446-8

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