Multicomponent Reactions Upon the Known Drug Trimethoprim as a Source of Novel Antimicrobial Agents

Novel antibiotic compounds have been prepared through a selective multicomponent reaction upon the known drug Trimethoprim. The Groebke-Blackburn-Bienaymé reaction involving this α-aminoazine, with a range of aldehydes and isocyanides afforded the desired adducts in one-step. The analogs display mea...

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Detalles Bibliográficos
Autores principales: Pedrola, Marina, Jorba, Marta, Jardas, Eda, Jardi, Ferran, Ghashghaei, Ouldouz, Viñas, Miguel, Lavilla, Rodolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621506/
https://www.ncbi.nlm.nih.gov/pubmed/31334221
http://dx.doi.org/10.3389/fchem.2019.00475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621506/
https://www.ncbi.nlm.nih.gov/pubmed/31334221
http://dx.doi.org/10.3389/fchem.2019.00475

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