The β2-adrenergic receptor antagonist ICI-118,551 blocks the constitutively activated HIF signalling in hemangioblastomas from von Hippel-Lindau disease

One of the major consequences of the lack of a functional VHL protein in von Hippel-Lindau disease, a rare cancer, is the constitutive activation of the HIF pathway. This activation ends up in the generation of Central Nervous System (CNS) Hemangioblastomas among other tumours along the lifespan of...

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Detalles Bibliográficos
Autores principales: Cuesta, A. M., Albiñana, V., Gallardo-Vara, E., Recio-Poveda, L., de Rojas-P, I., de Las Heras, K. Villar Gómez, Aguirre, D. T., Botella, L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624208/
https://www.ncbi.nlm.nih.gov/pubmed/31296894
http://dx.doi.org/10.1038/s41598-019-46448-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624208/
https://www.ncbi.nlm.nih.gov/pubmed/31296894
http://dx.doi.org/10.1038/s41598-019-46448-6

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