The β2-adrenergic receptor antagonist ICI-118,551 blocks the constitutively activated HIF signalling in hemangioblastomas from von Hippel-Lindau disease

One of the major consequences of the lack of a functional VHL protein in von Hippel-Lindau disease, a rare cancer, is the constitutive activation of the HIF pathway. This activation ends up in the generation of Central Nervous System (CNS) Hemangioblastomas among other tumours along the lifespan of...

Descripción completa

Detalles Bibliográficos
Autores principales: Cuesta, A. M., Albiñana, V., Gallardo-Vara, E., Recio-Poveda, L., de Rojas-P, I., de Las Heras, K. Villar Gómez, Aguirre, D. T., Botella, L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624208/
https://www.ncbi.nlm.nih.gov/pubmed/31296894
http://dx.doi.org/10.1038/s41598-019-46448-6

Ejemplares similares

Ejemplares similares