Excitotoxic targeting of Kidins220 to the Golgi apparatus precedes calpain cleavage of Rap1-activation complexes

Excitotoxic neuronal death induced by high concentrations of glutamate is a pathological event common to multiple acute or chronic neurodegenerative diseases. Excitotoxicity is mediated through overactivation of the N-Methyl-D-aspartate type of ionotropic glutamate receptors (NMDARs). Physiological...

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Detalles Bibliográficos
Autores principales: López-Menéndez, Celia, Simón-García, Ana, Gamir-Morralla, Andrea, Pose-Utrilla, Julia, Luján, Rafael, Mochizuki, Naoki, Díaz-Guerra, Margarita, Iglesias, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624258/
https://www.ncbi.nlm.nih.gov/pubmed/31296845
http://dx.doi.org/10.1038/s41419-019-1766-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624258/
https://www.ncbi.nlm.nih.gov/pubmed/31296845
http://dx.doi.org/10.1038/s41419-019-1766-z

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