Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation

CARD9 and CARD11 drive immune cell activation by nucleating Bcl10 polymerization, but are held in an autoinhibited state prior to stimulation. Here, we elucidate the structural basis for this autoinhibition by determining the structure of a region of CARD9 that includes an extensive interface betwee...

Descripción completa

Detalles Bibliográficos
Autores principales: Holliday, Michael J., Witt, Axel, Rodríguez Gama, Alejandro, Walters, Benjamin T., Arthur, Christopher P., Halfmann, Randal, Rohou, Alexis, Dueber, Erin C., Fairbrother, Wayne J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624267/
https://www.ncbi.nlm.nih.gov/pubmed/31296852
http://dx.doi.org/10.1038/s41467-019-10953-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624267/
https://www.ncbi.nlm.nih.gov/pubmed/31296852
http://dx.doi.org/10.1038/s41467-019-10953-z

Ejemplares similares