Combined treatment with emodin and a telomerase inhibitor induces significant telomere damage/dysfunction and cell death

G-quadruplex telomeric secondary structures represent natural replication fork barriers and must be resolved to permit efficient replication. Stabilization of telomeric G4 leads to telomere dysfunctions demonstrated by telomere shortening or damage, resulting in genome instability and apoptosis. Che...

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Detalles Bibliográficos
Autores principales: Liu, Rui, Liu, Jing, Wang, Shuqing, Wang, Yinsong, Zhang, Tao, liu, Yang, Geng, Xin, Wang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624283/
https://www.ncbi.nlm.nih.gov/pubmed/31296842
http://dx.doi.org/10.1038/s41419-019-1768-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624283/
https://www.ncbi.nlm.nih.gov/pubmed/31296842
http://dx.doi.org/10.1038/s41419-019-1768-x

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