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Combined treatment with emodin and a telomerase inhibitor induces significant telomere damage/dysfunction and cell death
G-quadruplex telomeric secondary structures represent natural replication fork barriers and must be resolved to permit efficient replication. Stabilization of telomeric G4 leads to telomere dysfunctions demonstrated by telomere shortening or damage, resulting in genome instability and apoptosis. Che...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624283/ https://www.ncbi.nlm.nih.gov/pubmed/31296842 http://dx.doi.org/10.1038/s41419-019-1768-x |