Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity

Thymidylate synthase (TS) is a hot target for tumor chemotherapy, and its inhibitors are an essential direction for anti-tumor drug research. To our knowledge, currently, there are no reported thymidylate synthase inhibitors that could inhibit cancer cell migration. Therefore, for optimal therapeuti...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xin-yang, Zhang, Ting-jian, Kamara, Mohamed Olounfeh, Lu, Guo-qing, Xu, Hai-li, Wang, De-pu, Meng, Fan-hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624297/
https://www.ncbi.nlm.nih.gov/pubmed/31296849
http://dx.doi.org/10.1038/s41419-019-1773-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624297/
https://www.ncbi.nlm.nih.gov/pubmed/31296849
http://dx.doi.org/10.1038/s41419-019-1773-0

Ejemplares similares