Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC

The AAA+ GTPase McrB powers DNA cleavage by the endonuclease McrC. The GTPase itself is activated by McrC. The architecture of the GTPase and nuclease complex, and the mechanism of their activation remained unknown. Here, we report a 3.6 Å structure of a GTPase-active and DNA-binding deficient const...

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Detalles Bibliográficos
Autores principales: Nirwan, Neha, Itoh, Yuzuru, Singh, Pratima, Bandyopadhyay, Sutirtha, Vinothkumar, Kutti R., Amunts, Alexey, Saikrishnan, Kayarat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624300/
https://www.ncbi.nlm.nih.gov/pubmed/31296862
http://dx.doi.org/10.1038/s41467-019-11084-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624300/
https://www.ncbi.nlm.nih.gov/pubmed/31296862
http://dx.doi.org/10.1038/s41467-019-11084-1

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