Suppression of MAP4K4 Signaling Ameliorates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis-Molecular Studies Toward New Therapeutics

Amyotrophic lateral sclerosis (ALS), the most common motor neuron (MN) disease of adults, is characterized by the degeneration of upper MNs in the motor cortex and lower MNs in the brain stem and spinal cord. Our recent work suggests that a MAP kinase family member, MAP4K4 (mitogen-activated protein...

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Detalles Bibliográficos
Autores principales: Watts, Michelle E, Wu, Chen, Rubin, Lee L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624916/
https://www.ncbi.nlm.nih.gov/pubmed/31320806
http://dx.doi.org/10.1177/1179069519862798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624916/
https://www.ncbi.nlm.nih.gov/pubmed/31320806
http://dx.doi.org/10.1177/1179069519862798

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