A thiochromenone antibiotic derived from the Pseudomonas quinolone signal selectively targets the Gram-negative pathogen Moraxella catarrhalis

The Pseudomonas quinolone signal (PQS) is an important quorum sensing signal of the pathogen Pseudomonas aeruginosa. We discovered an additional activity of PQS as a narrow spectrum antibiotic. Exploiting the privileged structure of PQS by the synthesis of heteroatom-substituted analogues led to a c...

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Detalles Bibliográficos
Autores principales: Szamosvári, Dávid, Schuhmacher, Tamara, Hauck, Christof R., Böttcher, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624978/
https://www.ncbi.nlm.nih.gov/pubmed/31367314
http://dx.doi.org/10.1039/c9sc01090d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624978/
https://www.ncbi.nlm.nih.gov/pubmed/31367314
http://dx.doi.org/10.1039/c9sc01090d

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