High-Affinity Bent β(2)-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis

Leukocyte adhesion requires β(2)-integrin activation. Resting integrins exist in a bent-closed conformation—i.e., not extended (E(−)) and not high affinity (H(−))—unable to bind ligand. Fully activated E(+)H(+) integrin binds intercellular adhesion molecules (ICAMs) expressed on the opposing cell in...

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Detalles Bibliográficos
Autores principales: Fan, Zhichao, Kiosses, William Bill, Sun, Hao, Orecchioni, Marco, Ghosheh, Yanal, Zajonc, Dirk M., Arnaout, M. Amin, Gutierrez, Edgar, Groisman, Alex, Ginsberg, Mark H., Ley, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625519/
https://www.ncbi.nlm.nih.gov/pubmed/30605669
http://dx.doi.org/10.1016/j.celrep.2018.12.038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625519/
https://www.ncbi.nlm.nih.gov/pubmed/30605669
http://dx.doi.org/10.1016/j.celrep.2018.12.038

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