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High-Affinity Bent β(2)-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis
Leukocyte adhesion requires β(2)-integrin activation. Resting integrins exist in a bent-closed conformation—i.e., not extended (E(−)) and not high affinity (H(−))—unable to bind ligand. Fully activated E(+)H(+) integrin binds intercellular adhesion molecules (ICAMs) expressed on the opposing cell in...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625519/ https://www.ncbi.nlm.nih.gov/pubmed/30605669 http://dx.doi.org/10.1016/j.celrep.2018.12.038 |