Dual PI3K/mTOR Inhibitor, XL765, suppresses glioblastoma growth by inducing ER stress-dependent apoptosis

Background: Deregulated phosphoinositide 3-kinase (PI3K)/mTOR signaling commonly exists in glioblastoma (GBM), making this axis an attractive target for therapeutic manipulation. A recent dual inhibitor of PI3K/mTOR pathway, XL765, exhibited an attractive suppression effect on GBM tumor growth. Howe...

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Detalles Bibliográficos
Autores principales: Zhao, Hang, Chen, Guangyong, Liang, Huaxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625605/
https://www.ncbi.nlm.nih.gov/pubmed/31360067
http://dx.doi.org/10.2147/OTT.S210128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625605/
https://www.ncbi.nlm.nih.gov/pubmed/31360067
http://dx.doi.org/10.2147/OTT.S210128

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