YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway

BACKGROUND: Multi-drug resistance is the major cause of chemotherapy failure in hepatocellular carcinoma (HCC). YAP, a critical effector of the Hippo pathway, has been shown to contribute to the progression, metastasis and invasion of cancers. However, the potential role of YAP in mediating drug res...

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Detalles Bibliográficos
Autores principales: Zhou, Yuan, Wang, Yubo, Zhou, Wuhua, Chen, Tianchi, Wu, Qinchuan, Chutturghoon, Vikram Kumar, Lin, Bingyi, Geng, Lei, Yang, Zhe, Zhou, Lin, Zheng, Shusen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626386/
https://www.ncbi.nlm.nih.gov/pubmed/31337986
http://dx.doi.org/10.1186/s12935-019-0898-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626386/
https://www.ncbi.nlm.nih.gov/pubmed/31337986
http://dx.doi.org/10.1186/s12935-019-0898-7

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