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Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor neurons in the brainstem, spinal cord and motor cortex. ALS is characterized by genetic and clinical heterogeneity, suggesting the existence of genetic factors that modify the phenotypic expression of the dis...

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Detalles Bibliográficos
Autores principales: Rué, Laura, Oeckl, Patrick, Timmers, Mieke, Lenaerts, Annette, van der Vos, Jasmijn, Smolders, Silke, Poppe, Lindsay, de Boer, Antina, Van Den Bosch, Ludo, Van Damme, Philip, Weishaupt, Jochen H., Ludolph, Albert C., Otto, Markus, Robberecht, Wim, Lemmens, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626434/
https://www.ncbi.nlm.nih.gov/pubmed/31300041
http://dx.doi.org/10.1186/s40478-019-0759-6