Emerging Allosteric Mechanism of EGFR Activation in Physiological and Pathological Contexts

Protein kinases are key players in signal transduction pathways where they are crafted into two functional states. In response to growth factor binding stimulus, epidermal growth factor receptor (EGFR), which is physiologically populated in an autoinhibited inactive state, becomes active. Here, we o...

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Detalles Bibliográficos
Autores principales: Tsai, Chung-Jung, Nussinov, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2019
Materias:
Biophysical Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626828/
https://www.ncbi.nlm.nih.gov/pubmed/31202480
http://dx.doi.org/10.1016/j.bpj.2019.05.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626828/
https://www.ncbi.nlm.nih.gov/pubmed/31202480
http://dx.doi.org/10.1016/j.bpj.2019.05.021

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