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Emerging Allosteric Mechanism of EGFR Activation in Physiological and Pathological Contexts
Protein kinases are key players in signal transduction pathways where they are crafted into two functional states. In response to growth factor binding stimulus, epidermal growth factor receptor (EGFR), which is physiologically populated in an autoinhibited inactive state, becomes active. Here, we o...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626828/ https://www.ncbi.nlm.nih.gov/pubmed/31202480 http://dx.doi.org/10.1016/j.bpj.2019.05.021 |