Improving the Repeatability and Efficacy of Intradermal Electroporated Self-Replicating mRNA

Local administration of naked self-replicating mRNA (sr-mRNA) in the skin or muscle using electroporation is effective but hampered by low repeatability. In this manuscript, we demonstrated that intradermal electroporation of sr-mRNA in combination with a protein-based RNase inhibitor increased the...

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Detalles Bibliográficos
Autores principales: Huysmans, Hanne, De Temmerman, Joyca, Zhong, Zifu, Mc Cafferty, Séan, Combes, Francis, Haesebrouck, Freddy, Sanders, Niek N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626868/
https://www.ncbi.nlm.nih.gov/pubmed/31307005
http://dx.doi.org/10.1016/j.omtn.2019.06.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626868/
https://www.ncbi.nlm.nih.gov/pubmed/31307005
http://dx.doi.org/10.1016/j.omtn.2019.06.011

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