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Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants

Myeloid-differentiated hematopoietic stem cells (HSCs) have contributed to a number of novel treatment approaches for lysosomal storage diseases of the central nervous system (CNS), and may also be applied to patients infected with HIV. We quantified hematopoietic stem and progenitor cell (HSPC) tra...

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Detalles Bibliográficos
Autores principales: Peterson, Christopher W., Adair, Jennifer E., Wohlfahrt, Martin E., Deleage, Claire, Radtke, Stefan, Rust, Blake, Norman, Krystin K., Norgaard, Zachary K., Schefter, Lauren E., Sghia-Hughes, Gabriella M., Repetto, Andrea, Baldessari, Audrey, Murnane, Robert D., Estes, Jacob D., Kiem, Hans-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626873/
https://www.ncbi.nlm.nih.gov/pubmed/31204301
http://dx.doi.org/10.1016/j.stemcr.2019.05.016