From Powerhouse to Perpetrator—Mitochondria in Health and Disease

In this review we discuss the interaction between metabolic stress, mitochondrial dysfunction, and genomic instability. Unrepaired DNA damage in the nucleus resulting from excess accumulation of DNA damages and stalled replication can initiate cellular signaling responses that negatively affect meta...

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Autores principales: Fakouri, Nima B., Hansen, Thomas Lau, Desler, Claus, Anugula, Sharath, Rasmussen, Lene Juel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627154/
https://www.ncbi.nlm.nih.gov/pubmed/31083572
http://dx.doi.org/10.3390/biology8020035
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author Fakouri, Nima B.
Hansen, Thomas Lau
Desler, Claus
Anugula, Sharath
Rasmussen, Lene Juel
author_facet Fakouri, Nima B.
Hansen, Thomas Lau
Desler, Claus
Anugula, Sharath
Rasmussen, Lene Juel
author_sort Fakouri, Nima B.
collection PubMed
description In this review we discuss the interaction between metabolic stress, mitochondrial dysfunction, and genomic instability. Unrepaired DNA damage in the nucleus resulting from excess accumulation of DNA damages and stalled replication can initiate cellular signaling responses that negatively affect metabolism and mitochondrial function. On the other hand, mitochondrial pathologies can also lead to stress in the nucleus, and cause sensitivity to DNA-damaging agents. These are examples of how hallmarks of cancer and aging are connected and influenced by each other to protect humans from disease.
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spelling pubmed-66271542019-07-19 From Powerhouse to Perpetrator—Mitochondria in Health and Disease Fakouri, Nima B. Hansen, Thomas Lau Desler, Claus Anugula, Sharath Rasmussen, Lene Juel Biology (Basel) Review In this review we discuss the interaction between metabolic stress, mitochondrial dysfunction, and genomic instability. Unrepaired DNA damage in the nucleus resulting from excess accumulation of DNA damages and stalled replication can initiate cellular signaling responses that negatively affect metabolism and mitochondrial function. On the other hand, mitochondrial pathologies can also lead to stress in the nucleus, and cause sensitivity to DNA-damaging agents. These are examples of how hallmarks of cancer and aging are connected and influenced by each other to protect humans from disease. MDPI 2019-05-11 /pmc/articles/PMC6627154/ /pubmed/31083572 http://dx.doi.org/10.3390/biology8020035 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fakouri, Nima B.
Hansen, Thomas Lau
Desler, Claus
Anugula, Sharath
Rasmussen, Lene Juel
From Powerhouse to Perpetrator—Mitochondria in Health and Disease
title From Powerhouse to Perpetrator—Mitochondria in Health and Disease
title_full From Powerhouse to Perpetrator—Mitochondria in Health and Disease
title_fullStr From Powerhouse to Perpetrator—Mitochondria in Health and Disease
title_full_unstemmed From Powerhouse to Perpetrator—Mitochondria in Health and Disease
title_short From Powerhouse to Perpetrator—Mitochondria in Health and Disease
title_sort from powerhouse to perpetrator—mitochondria in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627154/
https://www.ncbi.nlm.nih.gov/pubmed/31083572
http://dx.doi.org/10.3390/biology8020035
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